Recent discovery has revealed that a few
women have male DNA in their brain. During pregnancy, the male DNA produced in
a male fetus in the woman’s womb. It is believed that the cells can travel from
fetus to the mother’s brain through the blood and can cross the blood-brain
barrier.
The circulating blood and the brain’s
extracellular fluid (BECF) in the central nervous system (CNS) is separated by
the blood-brain barrier (BBB). The
endothelial cells act as a restrictor for the diffusion on cerebrospinal fluid
and microscopic objects such as hydrophilic molecules and bacteria while
allowing carbon dioxide, oxygen and hormones to diffuse.
We are serving life science community from several
years as a reputated drug manufacturing company. We are specialize in
manufacturing quality peptide synthesis,
custom peptide, custom antibody, amino acid analysis, long
RNA,
oligo synthesis etc.
Blood-brain barrier contains transport
cells that transfer metabolic products across the barrier such as glucose. The
astrocrytic endfeet and the thick basement membrane of the barrier act as a
filter as they prevent vital material from entering the brain.
Male progenitor cells can be present in
the blood of the mother for even 27 years after giving birth. The male DNA in
the female brain is termed microchimerism (Mc) which means the harboring of DNA
or cells that originated in a different individual.
Microchimerism is derived mainly from
the maternal cells in her offspring or the cells of fetal origin in women. The
traces of Fetal Mc and maternal Mc have been discovered in hematopoietic cells
including T and B cells, granulocytes and natural killer cells.
At the Fred Hutchinson Cancer Research
Center, researchers have studies the brains of 59 deceases women and male DNA
was found in 62 percent. Women in age group 32 to 94 have male DNA in various
regions of the brain. No connection could be established between the disease
and the male DNA in the female brain tissue. Other center studies suggest that
male Mc can impact the risk of developing autoimmune diseases and cancer. The
study was conducted with the help of qPCR to identify the male DNA by amplifying
the Y chromosome sequence DYS14.
The test showed that Mc is present
throughout the human lifespan and the oldest woman who had male fetal DNA in
the brain was 94.
Previous studies have suggested that
male Mc in the female brain may cause some autoimmune diseases and,
potentially, cancer. This paper describes the presence of male Mc in the female
human brain for the first time. The findings show that fetal cells may
frequently cross the human blood-brain barrier and that Mc in the brain is
relatively common. Mc was discovered in 63 percent of specimens and could be
detected in several brain regions.
The data indicated that Mc is has the
potential to be a relentless phenomenon throughout the span of human life. The
oldest woman in whom male fetal DNA ad been discovered in the brain happened to
be 94 years old. Of the women tested, Twenty six showed no neurological disease,
whereas 33 resulted in having Alzheimer's disease. The brains of women who
suffered Alzheimer's had a relatively lower occurrence of male Mc. However, it
was noted that the lesser number of specimens and chiefly unknown pregnancy
histories of the females does not let show that the presence of lower levels of
male cells, whose origins are fetal, could be the cause for Alzheimer's
disease.
For more information on Amino acid
analysis, Oligo Synthesis, Peptide Synthesis,
Please Visit : Long
RNA
